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arginine: glycine amidinotransferase (AGAT), summarized in Figure 3

Why they matter: Large randomised cardiovascular and renal outcome trials (EMPA-REG OUTCOME, DAPA-HF, DAPA-CKD, EMPEROR-Reduced/Preserved, CREDENCE, EMPA-KIDNEY) consistently showed reductions in heart-failure hospitalisation, progression of chronic kidney disease, and cardiovascular death

1,9 Platelet-rich plasma (PRP) is an autologous blood product obtained through the centrifugation of whole blood, therefore increasing the concentration of platelets up to 3 to 6 times higher their baseline values

Ipamorelin is a metabolite of growth hormone releasing peptides (GHRPs)

doi: 10.1016/j.cmet.2015.09.025